BACKGROUND Pan chewing causes Oral Sub-Mucous Fibrosis (OSMF) which is one of the major premalignant conditions of the oral cavity. It is seen mainly in South East Asia, Europe and North America. Malignant transformation to squamous cell carcinoma accounts for 2-3%. This risk is enhanced by the usage of pan and various tobacco products. MATERIALS AND METHODS We took up the present study in FH Medical College Etmadpur, Agra, from June 2017 to June 2018. 100 patients between the age group 21 years to 60 years where included in the study; who were attending outpatient department of ENT. RESULTS Most of them were having pan chewing as a habit. Pan chewing, tobacco chewing, and tobacco smoking were present in 16 patients. 78 patients were men. Most of the patients belonged to 30 to 39 age group. Conservative OPD treatment combined with surgical treatment gave good outcome in the treatment process. CONCLUSION We conclude that pan chewing and its various products has got strong association in the development of OSMF. Tobacco usage adds to the magnitude of the problem. Early diagnosis and treatment are important to prevent carcinomatous transformation.