Isotoma Longiflora Presi known as kitolod belongs to the Campanulaceae family. This plant is used as traditional medicine, and now continues to be in the process of moving towards conventional herbal medicine. Kitolod plants grow scattered on several islands in Indonesia, especially in the lowlands. This review article discusses the scientific journal of the kitolod plant which focuses on chemical compounds and also their pharmacological activities. All information exposure obtained from scientific literature such as scientific journals, the official website of the Minister of Health, books and also electronic books. Based on the results of a literature survey, Kitolod Plant (Isotoma Longiflora Presi). used in traditional medicine, used as anticancer, anti-inflammatory, anti-fungal, anti-bacterial, anti-oxidant, and is also able to help treat glaucoma and hyperlepidemia. Phytochemical compounds contained in this plant are alkaloids, flavonoids, tannins, saponins, terpenoids and steroids. This finding was obtained from both in vivo and in vitro testing and analysis of Isotoma Longiflora Presi.

Transdermal is a route of drug administration through the skin, where many lipid layers are difficult to penetrate so that transdermal preparations are needed as a place for drug entry, for example creams and gels. The mechanism of drug delivery is through diffusion of the stratum corneum layer through lipid molecules, before releasing the drug in a controlled and constant manner followed by various other benefits and aims to increase the pharmacological effect in order to reach the maximum level. However, the permeability of the drug is not strong enough to pass through the stratum corneum. So we need a transdermal preparation that can work optimally and overcome the obstacles. This study aims to demonstrate the form, evaluation, formulation, and application of transdermal preparations in new drug delivery systems. Method used literature review of the 10 most journal articles and contains related information. Based on the research results, transdermal dosage forms differ depending on the level of concentration and each technological method needs adapted to the characteristics  drug and the route of drug delivery given.

ABSTRAK Senyawa kimia dapat dijadikan sebagai bahan tambahan dalam pembuatan produk kosmetik dan pangan bila memenuhi dosis yang telah ditentukan. Berkembangnya inovasi produk kosmetika dan pangan yang beredar di pasaran yang disebabkan akibat tingkat pertumbuhan peminatan untuk penggunaan kosmetik dan konsumsi pangan. Pekembangan pada sektor kosmetik dan pangan di Indonesia telah berkontribusi pada perkembangan sektor perekonomian dimasyarakat. Terbukti dengan pesatnya permintaan konsumen akan produk kosmetika dan pangan sebagai akibat meningkatnya trend dan fashion serta inovasi pada masa kini, membuat banyaknya para pelaku usaha dalam meracik produk kosmetika dan pangan dengan campuran bahan kimia. Penambahan bahan kimia yang tidak disarankan oleh Lembaga yang berwenang dinilai dapat membahayakan konsumen.Kata Kunci: Etika Perundang-undangan, Kosmetika, Pangan, Bahan Kimia Berbahaya.

The development of the cosmetic industry that continues to increase has resulted in various circulations of serum products on the market, both in terms of brands, facilities, types, prices, and variations contained in these products. This fact makes it difficult for some consumers, especially those who do not understand about facial serum, to find facial serum products that are suitable for skin conditions. The use of herbal ingredients is an effort to reduce the side effects of cosmetics. This review aims to provide information about several types of plants that can be used as basic ingredients in the form of the active substance of this anti-Acne serum gel. This review is taken from several national and international journals released in the period from 2009 to 2021. There are various plants that have activity as antibacterial or anti-Acne active substances, namely Averrhioa limbi Linn, Pluchea Indica L, Carica Papaya L, Ocimum Basilicum L, Mangifera Indica L, Garcinia Mangostana L, Citrus Aurantifolia (CA), Annona Muricita L dan Muntingia Calabura L, Citrullus Lanatus Thunb. Some of these plants can be used as basic ingredients for making serum because they have excellent antibacterial activity.

Indonesia is known for its biodiversity of various types, for example, plants, in Indonesia there are around 9000 species of plants that have traditional medicinal properties, 5% as phytopharmaca ingredients, and 1000s of plant species that can be used as herbal medicine. People often manage traditional medicinal herbs with medicinal chemicals so that they are not by the regulations set by the government, this is evidenced by the findings of herbal medicine with medicinal chemicals (BKO).. This review article draws from several national and international research journals released in the period 2012-2022, there are findings of herbal medicine in the Bayuwangi area, Jakarta, Banyumas, Rengel District Market, Pekalongan, Bumiayu, Central Market, Curug District and Probolinggo with herbal findings that have efficacy and chemical content of drugs Glibenclamide (Diabetes Jammu), Sildenafil (Men's Strong Herbal Medicine), Furosemide, Phenolphthalein, Sibutramine (Slimming Herbal Medicine) Dexamethasone, Cyproheftadin (Appetite Enhancement Herb), Theophylline (Shortness of Breathing Herbal Medicine), Paracetamol and Phenylbutason (Jammu) Anti-Pain) was obtained from the Qualitative methods of Thin Layer Chromatography, Spectrophotodesintometry, High Performance Liquid Chromatography, UV-Visible Spectrophotometry, and FTIR