Abstract. We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of glutamate-cysteine ligase catalytic subunit mRNA, 1 day after injection. TMT produced a slight but significant elevation of GST activity during the period from day 1 to 7 post-treatment. No significant change was seen in the activity of glutathione peroxidase at anytime post-TMT treatment. Our data suggest the prolonged elevation of GST activity in the hippocampus following TMT treatment through enhanced expression of the GST Ya/Yc.

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Abstract:In view of the high prevalaence of periodontal disease, it is important for us to detect and treat the disease as early as we can. Therefore, using salivary occult blood test paper (Salivaster Bld), I examined gingivitis screening in a group of 117 employees of a company (average age 42.6 years). The results of the phenolphthalin method and the Salivaster Bld were the same in both the conventional 5-step evaluation and the 3-step evaluation. Therefore, the 3-step method is suitable for gingivitis screening, and gargled liquid should be used as specimens because its evaluation is simple and is subject to in mass applications.In most cases, a low correlation was noted between Salivaster Bld and each of the indexes indicative of the condition of gingivitis and periodontitis. However, since a high correlation (0.3-0.7) was noted with many of the indexes for a group of subjects up to their thirties, compared with lower values noted for older subjects, the application of Salivaster Bld appeared to be effective for those agegroups which have a high incidence of gingivitis.No sex difference was noted in the indexes.

Abstract:An opininon survey was made with a questionnaire on medical ethics and social responsibility, and then a comparison was made between dental students and dentists who had graduated from same dental college.The survey revealed the following opinions.The best policy in dental practice is to get the patient's trust, and to be kind to the patient. Dentists give more attention to attitudes of trust , kindness, and social responsibility than dental students.In the dentist's opininon, medical ethics should be taught in various departments of the university .