Introduction: Burn is the most devastating of all injuries and a major global public health crisis. Biological dressings with collagen create the most physiological interface between the wound surface and environment and are impermeable to bacteria. Collagen dressing is easily applicable, non-immunogenic, non-pyrogenic, hypo allergic and pain free. Collagen is an endogenous substance which forms an important structural component in connective tissue. By applying it over the wound, exposed dermis and free nerve endings get covered leading to reduction in pain and infection. Objective: To assess the efficacy of collagen dressing in burn wound management. Methods: Prospective interventional study was carried out at the Department of Burn and Reconstructive Surgery, faculty of Paediatric Surgery, Bangladesh Shishu Hospital & Institute. A total 20 patients were included in this study after fulfillment of all selection criteria during the study period. Result: The mean pain relief time, wound healing and hospital stay were 2.7±0.6 days, 7.3±1.0 days and 4.5±0.6 days respectively. Conclusion: Collagen dressing is safe and effective in the treatment of superficial partial thickness burn in children.