The key factors for activity of asbestos tailings acid leaching residue (ATALR) and activated process were researched by the way of orthoplan, so as to make a new type of high-active mineral admixture in cement-based material, named as porous silica fume (PSF). Then with the strength loss indexes designed, the sulfate attack resistance of cement-PSF mortars was evaluated, which was dunked in solution of sodium sulfate during from 6 to 12 months. The results indicated that thermal activated temperature and holding time was the key factor for compressive strength, while holding time and grinding time for flexural strength. The optimal activated process was the thermal activated temperature at800°C needing to hold for 1 hour before grinding for 20minuteswhilethe appropriate amount of PSF was 5%~12% in cement mortar. When 5%~8% PSF contained, the sulfate attack resistance of cement mortar can be improved obviously, and the role was similar to silica fume (SF). PSF activated from ATALR is helpful for resource utilization of asbestos tailings, in order to improve ecological environment in the asbestos mine town and promote cement-based material development.