Introduction: Boesenbergia rotunda is a famous culinary/medicinal herb native to Southeast Asia region and it is traditionally used in the treatment of several diseases. This study investigated the anti-diabetic properties of Boesenbergia rotunda polyphenol extract (BRE) in high fructose/streptozotocin-induced diabetic rats. Method: The in vitro antioxidant activity was evaluated using DPPH and ABST colorimetric assays, while the Folin-Ciocalteu method was used for the total phenolic content of BRE. For diabetes induction, a combination of high fructose solution and streptozotocin was administered to the rats and diabetic rats were orally administrated with BRE (100 and 400 mg/kg) for 5 weeks. The fasting blood glucose, body weight gain, food and water consumption were determined during the treatment period. Results: BRE showed excellent in vitro DPPH and ABTS scavenging activity with high phenolic content. BRE significantly lowered fasting blood glucose level, HbA1c, lipid profile, hepatorenal biochemical parameters and ameliorated the IPGTT in diabetic rats. Additionally, BRE reversed body weight loss, attenuated food and water intake, serum insulin level, pancreatic β-cell function and pancreatic cell morphology. Furthermore, fructose 1,6 biphosphatase, glucose-6-phosphatase, malondialdehyde (MDA) and proinflammatory cytokines levels were also ameliorated in the BRE-treated diabetic rats, while pancreatic antioxidant enzymes activities (GSH, SOD and CAT) were significantly increased in the treated rats. Conclusions: In conclusion, the results showed that BRE effectively displayed antidiabetic effects and has possible value for antidiabetic oral medication.

Background Since March 2022, Shanghai, China, has been affected by a severe outbreak of COVID-19, which has caused tens of thousands of people to become ill. To prevent and control this disease, Shanghai has implemented strict isolation measures, including arrangements for isolation of individuals in close contact, at isolation shelters in Tongling City, Anhui Province. Isolation may have significantly affected the quality of life and psychological status of such individuals. Therefore, the purpose of this study was to evaluate the quality of life and anxiety of people isolated in different shelters during the COVID-19 pandemic and to analyze the influencing factors. Methods This is a cross-sectional study. An online survey was conducted from April 20 to May 10, 2022. A total of 279 people in close contact with an isolation shelter in Tongling City, Anhui Province, participated in the survey. The quality of life was assessed using the Quality of Life Scale (SF-12), and anxiety status was assessed using the SAS. The study used descriptive analysis, t-tests, analysis of variance, and generalized linear regression analysis to test the factors influencing quality of life and anxiety during the COVID-19 pandemic, as well as the correlation between the two. Results The survey results showed that isolation days and marital status affected psychological and physical aspects, respectively. Age above 40 years was an independent risk factor for PCS, education was a protective factor for psychological status, and low quality of life directly led to an increase in anxiety levels. Conclusion During the pandemic, with infected individuals in close contact were isolated at shelters in other places. Reduction in the quality of life can lead to an increase in the anxiety levels of the population. We should pay attention to the age and education levels of individuals in isolation and take response measures to improve the health status of the isolated population.