Primary adenocarcinoma arising in the sublingual gland is extremely rara, accounting for six cases reported in extensive survey of the literature for the period of 1930 to 1981. A case of adenocarcinoma of the sublingual gland is documented, demonstrating a highly malignant nature of the disease. This neoplasm possesses particular therapeutic problems owing to the relative lack of symptoms and the delay of initial medical observation after the onset of symptoms.

Fifty four-year-old patient with unresectable hypopharyngeal cancer of T4N2cM0 was treated with accelerated hyperfractionated radiotherapy (1.5Gy twice a day) and hyperthermia. Good tumor response was achieved by combined four sessions of hyperthermia with radiotherapy of 75Gy. Laryngopharyngectomy, cervical esophagectomy, and bilateral neck dissection were performed for regrowth of the primary site 2.5 months after thermoradiotherapy. There were no viable cells in all metastatic nodes although scattered cancer nests were seen in the primary site. He has a local disease-free eleven months after resection.

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