Abstract BACKGROUND As people get older, body functions in the elderly will decrease so that it will affect their quality of life. One way to improve the quality of life of the elderly is to meet the basic needs of the elderly through a spiritual approach (Islamic psychotherapy).    AIM: This study aims to determine the effect of Zikr on the quality of life of the elderly in nursing homes.    METHODS: This study used a quasi-experimental nonequivalent control group design. The sampling technique used purposive sampling , a total of 10 respondents from the intervention group and 10 respondents from the control group. Quality of life score using the World Health Organization Quality of Life-BREF questionnaire (WHOQOL-BREF). The research analysis used paired t-test and Wilcoxon test for differences in quality-of-life scores of each group and for differences in quality of life between the intervention group and control group using unpaired t-test and Mann-Whitney test.    RESULTS: The effect of psycho-religious therapy (Zikr) on the quality of life of the elderly in the intervention group before and after doing Zikr (p = 0.000), there were differences in 3 domains of quality of life, namely the psychological domain ( p = 0.000), the domain of social relations (p = 0.027), and the environmental domain.  p = 0.010).    CONCLUSION: Psycho-religious therapy (Zikr) affects the quality of life of the elderly in the nursing home and suggests Nursing homes to provide guidance with a religious approach, especially Zikr to improve the quality of life of the elderly.