Background:Thyroid hormones have a central regulatory role in body hemodynamics, thermoregulation, and metabolism. The profound influence of thyroid hormones is observed on renal hemodynamics, glomerular filtration, renin-angiotensin-aldosterone system, and electrolyte balance. Thus, our main aim was to find out the electrolytes imbalance between subclinical hypothyroidism (SHO) and subclinical hyperthyroidism (SHE) and their correlation. Materials and methods: In our study, newly diagnosed 50 SHO and 35 SHE cases were selected. Blood samples were collected to analyze serum electrolytes (sodium, potassium, and chloride) by Electrolyte Analyzer from Roche. Mean, median, standard deviation, minimum value, maximum value, standard error of mean, and values at 95% confidence interval are calculated for the parameters. And the correlation between serum electrolytes with serum TSH was assessed. Results: There were no significant changes in levels of serum electrolytes in SHO and SHE, but the correlation between the levels of serum sodium and potassium with TSH showed little negativity or no changes in SHO and SHE, whereas the levels of serum chloride showed little positivity or no changes with TSH in SHO and little negativity or no changes with TSH in SHE. Conclusion:Hypothyroid and hyperthyroid patients in subclinical conditions will be having electrolyte imbalances and should be regularly checked for serum electrolytes. Also, electrolyte disturbances need to be monitored and treated appropriately to prevent further complications.