BACKGROUND:Uterine leiomyoma is the most common benign tumour of uterus affecting women of reproductive age group and accounting for most common indication of hysterectomy in India. Effective medical treatment option can prevent hysterectomy related morbidity. MATERIALS AND METHODS:A total of 50 women with symptomatic leiomyoma and asymptomatic with uterine volume >160cc and fibroid size >2.5cm were included in the study. 20mg/day mifepristone was given to them over period of 3 months. Follow up was done at 1, 3 and 6 months of starting treatment. At each visit patients were evaluated for symptomatic improvement of menorrhagia, dysmenorrhoea and ultrasound for myoma volume, haemogram was done. Endometrial biopsy was done at the beginning of therapy, 3 rd month and at end of treatment. RESULTS: At the beginning of study, all patients had menorrhagia. At 3 months, 80% developed amenorrhea and 20% scanty menses. At 6 months, 56% had scanty menses and 38% had normal menses but none had menorrhagia. 50% of patients had dysmenorrhoea at the beginning of study with severe dysmenorrhoea in 36% of cases. Only 10% of patients at 3 months and 14% at 6 months had dysmenorrhoea. Improvement in haemoglobin percentage from 9.6 gram% to 10.8 gram% at 3 months of therapy. The reduction in mean uterine volume was 12.28%after 1 month, 26.95% after 3 months and 11.13% at end of 6 months, as compared to pre-treatment level. Fibroid volume decreased by 14.34% after 1 month ,29.8% after 3 months and 24.98% at end of 6 months, as compared to pretreatment level. At the end of 3 months, 50% of patients experienced no side effect. Rest 50% experienced minor side effects like nausea (8%), hot flushes (4%), liver dysfunction as evidenced by mild increase in transaminase (8%) and simple endometrial hyperplasia in 30%. Follow up of these patients at 6 month i.e., 3 months after stopping the drug does not show any evidence of persistence of these effects. CONCLUSION: 20mg mifepristone produces reduction in myoma size, uterine volume and improvement of symptoms like menorrhagia and dysmenorrhoea. It is administered orally, cost effective and is well tolerable with less side effects.

Dual midline ventral hernia although not very common, a combination of infraumbilical with incisional hernia is unique. A obese lady in her sixth decade of life was diagnosed as having this unique combination and was treated by meshplasty and removal of umbilicus. Postoperative period was uneventful and patient discharged on 7th postoperative day.

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As the spirit of PC, programming has increasingly more significant effect on humanbeings. GUI (Graphical User Interface) innovation is generally utilized as a result of its accommodating point of interaction and simple activity. The meaning of ideal position is setting explicit; it targets augmenting quantifiable parts of the client experience, and it is determined utilizing master information installed in the framework, which depends on HCI standards, client studies, and information examination. The Quality of web applications are currently prima center. As mostof the exchanges like online business, banking and e-administration are done on the web, having a web application to accompany quality factors and secure is presently the need. It has been observed that stylish elements are unequivocal in choosing the nature of web application. The framework recognizes the site classification, assembles a format model, contrasts it and the pertinent ideal model, and suggests an elective design of intelligent components. The framework is carried out as an open-source programming, and it at present backings the re-situating of a solitary intuitive component. In the paper, we talk about a further speculation of this way to deal with help a bigger number of intuitive articles in a more extensive range of situations.