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This article is an examination of reviewing major microbes as a single cell protein (SCP). The scientific development and subsequent analysis of the potential of commonly found microorganisms to be used as a source of proteins in the form of single cell proteins. continues to influence the researchers all over the globe today. This article examines the research done and published by researchers and scientists. Consideration of current trends and data in scientific queries and demonstrates further aspects of Reviewing Major Microbes as a Single Cell Protein. Additionally, this article explores options for Rhodobacter capsulatus, Lactobacillus acidophilus, Saccharomyces cerevisiae, Saccharomyces boulardii, Spirulina, Chlorella, Trichoderma and Polysporous and their potential to produce single cell proteins from waste products such as wastewater, fruit peels and fermentation waste products. This single cell protein can be used for reducing inflammation, combating hyperlipidaemia and showing anti-viral effects. Keywords: Chlorella, Polyporous, Lactobacillus, Saccharomyces, Single cell protein (SCP), waste