Abuse of substance is increasing among youngsters since last few years, so as the crime rate. There are many factors responsible for the rapid raise of this problem. In spite of government regulations, it has not been decreasing. In each and every corner of Indian states, although law enforcement officers are taking strict action to control the drug trafficking and paddling, there are some linking chains which are yet to be cut. In this regard, role of forensic experts play vital role starting from the core problem up to tracing of the material and confirming it. This article highlights few things regarding the substance abuse, role of forensic experts and a light towards pharmacovigilance.