ImportanceSARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals.ObjectiveTo develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections.Design, Setting, and ParticipantsProspective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling.ExposureSARS-CoV-2 infection.Main Outcomes and MeasuresPASC and 44 participant-reported symptoms (with severity thresholds).ResultsA total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%]) were PASC positive at 6 months.Conclusions and RelevanceA definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC.

We investigate various pursuit-evasion parameters on latin square graphs, including the cop number, metric dimension, and localization number. The cop number of latin square graphs is studied, and for k-MOLS(n), bounds for the cop number are given. If n > (k + 1) 2 , then the cop number is shown to be k + 2. Lower and upper bounds are provided for the metric dimension and localization number of latin square graphs. The metric dimension of backcirculant latin squares shows that the lower bound is close to tight. Recent results on covers and partial transversals of latin squares provide the upper bound of n + O log n log log n on the localization number of a latin square graph of order n.

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Let $G$ be a graph with vertex set $\{1,2,\ldots,n\}$. Its bond lattice, $BL(G)$, is a sublattice of the set partition lattice. The elements of $BL(G)$ are the set partitions whose blocks induce connected subgraphs of $G$. In this article, we consider graphs $G$ whose bond lattice consists only of noncrossing partitions. We define a family of graphs, called triangulation graphs, with this property and show that any two produce isomorphic bond lattices. We then look at the enumeration of the maximal chains in the bond lattices of triangulation graphs. Stanley's map from maximal chains in the noncrossing partition lattice to parking functions was our motivation. We find the restriction of his map to the bond lattice of certain subgraphs of triangulation graphs. Finally, we show the number of maximal chains in the bond lattice of a triangulation graph is the number of ordered cycle decompositions.