No abstract

Pyrazoles are important nitrogen containing 5-membered heterocyclic compounds. Numerous pyrazoline derivatives have been found to possess considerable biological activities, which stimulated the research activity in this field. Several 1,3,5-Triphenyl-1H-pyrazole containing 6-aminopyridazin-3(2H)-one derivatives has been synthesized. These new compounds were characterized using IR, 1 H-NMR and Mass spectra and Elemental analysis. They possess some potent biological activities. Therefore biological screening of novel compounds has been also done.

Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in the presence of hydroxylamine hydrochloride. Isoxazoline is an important class of nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active compounds have been synthesized using it as an intermediate. Due to this activity, it is found useful in the treatment of anti-fungal, anti-bacterial, anti-cancer, anti-amoebic, and anti-inflammatory agents. The structures of the isoxazoline derivatives were confirmed by spectral analysis. The synthesized isoxazoline shows moderate activity against bacteria and fungus.