No abstract

Herbal medicine (also Herbalism) is the study of pharmacognosy and the use of medicinal plants. Plants have been the basis for medical treatments through most of human history, and such traditional medicine is still widely practiced today. Archaeological evidence indicates that the use of medicinal plants dates back to the Paleolithic age, approximately 60,000 years ago. Written evidence of herbal remedies dates back over 5,000 years to the Sumerians, who compiled lists of plants.

Objective: A new, simple, economical, precise, sensitive, linear, accurate, rapid UV spectrophotometric method has been developed for the estimation of Oseltamivir Phosphate in pure form and pharmaceutical formulation. Methods: This UV method was developed using Methanol as a solvent. In the present method, the wavelength selected for analysis was 218 nm. UV-Visible double beam spectrophotometer (Systronic 2201) was used to carry out spectral analysis. The ICH guidelines were used to validate the method. Results: The method was validated for linearity, range, accuracy, precision, robustness, LOD and LOQ. Linearity was found in the range of 10-50µg/ml. Accuracy was performed by using a recovery study. The amount of drug recovered was found to be in the range of 99.01-100.1%. The % RSD value was found to be less than 2. Conclusion: The developed UV spectrophotometric method was found to be simple, economic, sensitive, easy, accurate, linear, specific and highly sensitive and can be used for routine estimation of Oseltamivir Phosphate.

The aim of the present study was to formulate and evaluate Posaconazole loaded NLCs gel using solid lipid as GMS, liquid lipid as oleic acid and surfactants as tween 80 and span 80, with the help of high-speed homogenization followed by sonication technique to improve the bioavailability, to avoid the oral side effects, to achieve the site-specific delivery and to improve the patient compliance. NLCs of Posaconazole was prepared with different drug: carrier ratios using high speed homogenization followed by sonication technique. % entrapment efficiency for F3 batch of NLC was found to be more than 95%. SEM studies were carried out and depending on it F3 batch was found to have particle size range 200nm which was selected as optimized NLCs batch. IR, XRD and DSC were performed to identify the physicochemical interaction between drug and optimized formulation. The optimized NLCs was then incorporated into gel base to form Posaconazole loaded NLCs gel. The prepared NLCs gel were evaluated for viscosity, pH, spread-ability, extrudability and in-vitro drug release studies. It was found to be 34666 cps, 5.7, 12.22 ±0.8 cm, 85.34% and drug release of NLCs gel within 6hrs was 98.62% respectively. The obtained data for in-vitro drug release was putted in various mathematical kinetic models. Hence, F3 batch was selected as optimized batch.

No abstract