The study was conducted on patients of organophosphate poisoning admitted to Bapuji Hospital (J. J. M. Medical College), Davangere during a period of October 2011 to March 2013. To know the incidence of acute Organophosphate poisoning, epidemiological aspects of the patient and plasma pseudocholinesterase levels at the time of admission and correlation within hospital mortality. Total number of cases studied were 150. At the time of admission blood was drawn for estimation of plasma pseudocholinesterase estimation. The patients were clinically divided into three grades according to Dreishbachs criteria. Analysis was performed by cobas integra 400 cholinesterase assay system. All patients were followed-up for 3 days to know the outcome. Majority of the cases (40%) belong to 21 to 30 years age group and predominantly belonged to male sex (73%). Seventy eight cases (52%) had severe poisoning, 40 cases (26.67%) had moderate poisoning and 32 cases (21.33%) had mild poisoning. Sixty cases (40%) had fatal outcome. Suicidal consumption was seen in 128 cases (85.33%). Plasma pseudocholinesterase levels associated with fatalities in severe poisoning and was found to range from 912 to 2490 U/L which accounts to suppression of plasma pseudocholinesterase levels by 84.04 to 93.19%.