Both LMNB1 depletion and overexpression inhibit proliferation, but only LMNB1 overexpression induces senescence.

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The introduction of a spring-supported nasal tip model provided a more accurate representation of the boundary conditions in the nose. The bony-cartilaginous junction and the nasal spine were found to be the consistent points of maximum stress, regardless of material properties. The preservation of an arc of cartilage and a wider dorsal strut increased the stability of the structure.