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Multidrug resistance (MDR) is am ajor obstacle in the clinical treatment of cancer.H erein, af acile strategy is reported to construct av ersatile DNAn anostructure as ac odelivery vector of RNAi nterference (RNAi)a nd chemodrugs to combat multidrug-resistant tumor (MCF-7R) in vitro and in vivo.I nt he tailored nanocarrier,t wo linear small hairpin RNA( shRNA) transcription templates targeting MDR-associated genes (gene of P-glycoprotein, at ypical drug efflux pump;a nd gene of survivin, ar epresentative anti-apoptotic protein) are precisely organized in the chemodrug (doxorubicin, DOX) pre-loaded DNAo rigami. With the incorporation of active targeting and controlled-release elements,t hese multifunctional DNAn anocarriers can successfully enter the target MCF-7R cells and synergistically inhibit tumor growth without apparent systemic toxicity.T his tailored DNAn anoplatform, whichc ombines RNAi therapya nd chemotherapy, provides anew strategy for the treatment of multidrug-resistant tumors.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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