and the requirements for appropriately credentialed staff on a 24/7 schedule. Although clinical laboratories reflect many aspects of traditional production systems, the medical profession is, as are most specialized areas of practice, much more willing to entertain modeling approaches that describe their systems with domain-appropriate terminology and semantics. This thesis discusses the development of a framework for creating domain-specific simulation objects for modeling clinical laboratories. These objects are developed based on the chemistry laboratory at Seattle Children's Hospital. In addition, three case studies are conducted to demonstrate the applicability of the objects.