As the body works both day and night, genetics influences how effectively an organism adapts to a changing environment. During diseases, conditions like asthma, ulcers, and rheumatoid arthritis need treatment at certain times of the day. We require pulse drug delivery to avoid unwanted side effects depending on the disease condition. Its ability to prevent drug receptor downregulation and provide effective therapeutic effects has made pulsatile drug delivery a preferred method for treating diseases governed by the body's circadian cycle. The pulsatile release is used for drugs when a steady drug release (zero-order release) is undesirable. In time-controlled TCS systems, the delivery system controls the drug release. In stimulus-induced PDDS systems, the drug release is governed by stimulation factors like pH, temperature, and enzymes; external stimuli like magnetic, electric, and ultrasonic stimulation impact the drug release.The above-mentioned releasing mechanism is used by marketed technologies such as CODAS®, IPDAS®, etc. Pulsatile drug delivery systems are well suited for drugs with chronopharmacological characteristics and dose needs throughout the night.A pulsatile drug delivery system ensures that medications are administered to patients with chronic diseases such as asthma, hypertension, and rheumatoid arthritis at the right place, right time, right location, and the right dose.