Trichomonas vaginalis causes the most common, nonviral sexually transmitted infection. Only metronidazole (Mz) and tinidazole are approved for treating trichomoniasis, yet resistance is a clinical problem. The gold(I) complex, auranofin, is active against T. vaginalis and other protozoa but has significant human toxicity. In a systematic structure−activity exploration, we show here that diversification of gold(I) complexes, particularly as halides with simple C1−C3 trialkyl phosphines or as bistrialkyl phosphine complexes, can markedly improve potency against T. vaginalis and selectivity over human cells compared to that of the existing antirheumatic gold(I) drugs. All gold(I) complexes inhibited the two most abundant isoforms of the presumed target enzyme, thioredoxin reductase, but a subset of compounds were markedly more active against live T. vaginalis than the enzyme, suggesting that alternative targets exist. Furthermore, all tested gold(I) complexes acted independently of Mz and were able to overcome Mz resistance, making them candidates for the treatment of Mz-refractory trichomoniasis.

Developing metal-organic framework (MOF)-based proton-conducting electrolytes for fuel-cell applications is an important target that has drawn a lot of attention. A key approach involves the selective replacement of the guest species within the pores to enhance performance. The modular and crystalline nature of the MOF permits controlled introduction of such species and characterization of their compositions with high precision, a task which is very difficult to achieve in amorphous polymers. Herein, we partially replaced the protons of a

The first stereocontrolled total synthesis of 4(S),5(S)-oxido-17(S)-hydroxy-6(E),8(E),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid (1) is reported.

Background: Specialised female surgical clinics are the need of the day and not addressed routinely in the Surgical Department. The management of surgical problems in female patients requires multidisciplinary approach mainly general surgery, obstetrics and gynaecology, general medicine, paediatrics, dermatology and psychiatry. The aim and objective was to introduce a new concept of subspecialty and super speciality in management of female surgical diseases.Methods: Prospective educational interventional study. 18 out of 60 sensitised interns were introduced and oriented in the specialised female surgical clinic. A total of 952 patients visiting the Clinic were studied. Statistical analysis was done.Results: Feedback of female patients were taken and recorded in a proformas and their analysis was done. There was a significant improvement in the knowledge and skill of the participating interns.  99.2% (944 cases) of the female patients were willing to continue their visit to such a specialized clinic in future.Conclusions: It can be concluded that there is a requirement and need of a fully functional specialized female surgical Clinic in our hospital.

In this day and age, software is an indispensable part of our per diem endeavours, thereby keeping a check on exploitable vulnerabilities has become a vital function of a software firm. The motivation of this paper is to have better understanding of vulnerabilities, creating a tool for the industry practitioners to identify a critical vulnerability that could be detrimental for the firm's assets. In this article, 1999 vulnerabilities related to Google Chrome was analysed to understand the behaviour of vulnerabilities. The identification of trends and patterns using topic modelling technique led to extraction of topics. The extricated topics were then implemented in 10 classifiers to foresee the criticality of the vulnerability. The resulting performances were also assessed with the classifiers without implementing topic modelling techniques. A 10-fold validation was conducted on the suggested prediction model.Povzetek: Metoda za ugotavljanje občutljivosti programske opreme je narejena s pomočjo tem.