Simple, rapid, sensitive, precise and specific UV Spectrophotometric for the determination of cetilistat in API and pharmaceutical dosage form were developed and validated. In this method solutions of cetilistat were prepared in n-hexane. Cetilistat standard solution was scanned in the UV range (400-200nm) in a 1cm quartz cell in a double beam UV spectrophotometer. The standard solution of cetilistat showed maximum absorption at wavelength 320.0 nm. The method obeys Beer's law in the concentration range from 20-100µg/ml. The correlation coefficient was found to be 0.9996 and regression of the curve was found Y=0.0096x+0.0012 with excellent recovery 96-99%. Limit of detection and limit of quantification were found to be 2.7283µg/ml and 8.2677µg/ml respectively. The ruggedness and robustness were performed. The method was validated for several parameters like accuracy, precision as per ICH guidelines. Statistical analysis proved that the methods are repeatable and specific for determination of the said drug. These methods can be adopted in the routine assay analysis of cetilistat in API and pharmaceutical dosage form.

Mosquito born diseases are nauseous for human being life and were always a never ending hazard .They have also developed a resistance to this chemical insecticides. Alternatively bio-pesticides are been used. In Indian the Lanata camara , Parthenium hysterophorus are weeds that shows the larvicidal activity along with the Allium sativum linn. The present studies has shown the positive results of larvicidal activity. And the methanol as the choice of extract for the extraction process. Formulation of larvicidal sachets and it's evaluation were done. Leading to sachets formulation which shown high solubility and stability. With the dose dependent activity and showing the effective measures at low concentrations. Which is economical and ecofriendly less toxic then chemical synthetic pesticides, user -friendly, easy availability. Control and prevention of Mosquito larvaes ,using herbs showing larvicidal activity in sachets formulation.

In this study crude leaf extract of Parthenium, were tested for their larvicidal activity. The different solvents were used namely ethanol, methanol, water (aqueous) for the preparation of crude extracts from the plant leaves. The larval mortality after 24 hours of exposure were observed separately at concentration like 0.2mg, 0.4mg and 1m extract. The different concentration solvent extract of the plants showed good larvicidal activity. The highest potency was recorded by methanol extract of Parthenium. From These results it was observed that the leaf extract of parthenium contain toxic compounds to mosquito larvae and therefore suggest that parthenium extract has potential in the control of the malaria control and prevention of larvae for social health and can be developed and used.

Lycopene is dominant acyclic carotenoid pigment (chemically) found in tomato, watermelon, papaya, and red pepper. It is powerful antioxidant that may help protect cells from damage. [10] The most important sources of lycopene are tomatoes (Lycopersicon esculentum L.) although it can also be synthesized by the fermentation of fungi or by using bacteria"s. [2]

Hibiscus rosasinensis Linn are used in medicines in emollients and also it is used to treat burning sensations and skin disease. Mucilage of Hibiscus rosasinensis contains L-rhamnose, D-galactose, D-galactouronic acid, and D-glucuronic acid. The present article is trying to present an investigation is to extract the mucilage from the petals of flower of Hibiscus rosasinensis and use it in a paracetamol tablets as a binder. As the mucilage having granulating and binding properties so it is used in tablets, using paracetamol as a model drug. The Ph of mucilage was found to be 6.5 and all the physicochemical properties i.e. solubility and swelling index was studied. In this investigation wet granulation technique is used for the formation of granules using the above described mucilage which having the concentration of 2%, 5% and 7% w/v to use as a binder.'