In recent years, mobile healthcare has received increasing attention. As the wrist-pulse diagnosis in traditional Chinese medicine(TCM) only needs the wrist pulse information of a patient, without any other physiological data and invasive checking, it is a promising technique for mobile healthcare in terms of cost and convenience. But the pulse-based diagnosis requires the sophisticated and long-term training of the physicians. So it is urgent to develop a digitalized method to objectify and standardize the pulse-based diagnosis process. In this paper we design a wrist-pulse sensing and analyzing prototype system which involves a general pulse-sensing device and a cirrhosis diagnosis scheme based on the captured pulse information. The experimental results show that the accuracy of the proposed system reaches to 87.09% in cirrhosis identification.

Objective Leukoaraiosis (LA), as an age‐related white matter degeneration, is mainly caused by chronic ischemia. Our study aims to explore the efficacy of different doses of atorvastatin (ATV) in the vascular endothelial function in patients with LA. Methods Our study enrolled 402 LA patients who were then randomly included as control or treated with ATV (10 mg), ATV (20 mg), or ATV (30 mg). The total cholesterol (TC), triglycerides (TG), high‐density lipoprotein cholesterol (HDL‐C), and low‐density lipoprotein cholesterol (LDL‐C) were detected by enzyme colorimetric assay. The high‐sensitivity C‐reactive protein (hs‐CRP) level, reactive hyperemia index (RHI), endothelin‐1 (ET‐1) content, and nitric oxide (NO) level were tested by latex agglutination test, peripheral arterial tonometry technology, radioimmunoassay, and nitrate reductase assay, respectively. Results After 8 weeks of ATV treatment, the levels of TC, LDL‐C, and HS‐CRP decreased significantly, and the trends were demonstrated in a more significant way with the increases of dose of ATV. The treatment with ATV at different doses elevated NO level and RHI and declined ET‐1 content. Gastrointestinal reaction, muscular pain, and increased aminopherase were observed after treatment with the ATV at different doses with more obvious symptoms detected accompanied by the increase of the dose. The RHI was in negative correlation with the ET‐1 and HS‐CRP while in positive correlation with NO. Conclusion Our study demonstrates that ATV can significantly improve the vascular endothelial function in LA patients with a dose‐dependent effect.