An Ir­(I)/squaramide cooperative catalytic strategy for atroposelective synthesis of axially chiral aryltriazoles has been developed for the first time. Diverse structurally novel aryltriazole skeletons that cannot be accessed by traditional click reactions were synthesized in good yields with excellent enantioselectivity. Both enantiomers were easily obtained from a pair of diastereoisomeric natural quinidine- and quinine-derived squaramides. A significant Ir­(I)/squaramide coordination activation, but no self-quenching phenomenon was observed in this metal/organo cooperative catalytic system.

The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is regarded as a prime example in "click chemistry", but the asymmetric click cycloaddition of internal alkynes still remains challenging. A new asymmetric Rh-catalyzed...

We report herein an efficient Ni(II)/Feng ligand-catalyzed asymmetric Hetero-Diels-Alder reaction between conjugated vinyl azides with carbonyl groups. This method provides a platform for the synthesis of complicated chiral azido polyclcles...

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