An environmental thermal comfort model has previously been quantified based on the predicted mean vote (PMV) and the physical sensors parameters, such as temperature, relative humidity, and air speed in the indoor environment. However, first, the relationship between environmental factors and physiology parameters of the model is not well investigated in the smart home domain. Second, the model that is not mainly for an individual human model leads to the failure of the thermal comfort system to fulfill the human’s comfort preference. In this paper, a cyber–physical human centric system (CPHCS) framework is proposed to take advantage of individual human thermal comfort to improve the human’s thermal comfort level while optimizing the energy consumption at the same time. Besides that, the physiology parameter from the heart rate is well-studied, and its correlation with the environmental factors, i.e., PMV, air speed, temperature, and relative humidity are deeply investigated to reveal the human thermal comfort level of the existing energy efficient thermal comfort control (EETCC) system in the smart home environment. Experimental results reveal that there is a tight correlation between the environmental factors and the physiology parameter (i.e., heart rate) in the aspect of system operational and human perception. Furthermore, this paper also concludes that the current EETCC system is unable to provide the precise need for thermal comfort to the human’s preference.

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