Informing women preconceptionally on the importance of modifiable risk factors, such as body weight and maternal age before pregnancy, can be useful, considering that stretch marks are carried for a lifetime and there is no conclusive treatment.

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Our study suggests that increased MPV and total bilirubin levels are associated with preterm delivery, and increased postprandial total SBA levels are predictive for low APGAR in ICP patients.

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Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case-control study. Setting Education and Research Hospital. Patients Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age-matched, normal weight healthy controls. Interventions Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA-IR) were calculated. Main outcome measures The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS. Results Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0Á002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0Á001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405Á45 lmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1Á019, 95% CI: 1Á001-1Á036). In addition, a LAP index greater than 21Á54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1Á270, 95% CI: 1Á174-1Á374). ConclusionIn conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.