Background: Curiosity in view of the literature regarding breast cancer especially in our country, there has been little study on breast cancer individuals during and progression of the cancer on oxidative stress markers. Aim: To determine the effect of MDA, TAC, SOD, Catalase, reduced glutathione in breast cancer subjects and to compare them with the apparently healthy controls. Methods: Lately diagnosed female subjects with breast cancer in the age group of 40-60 years were included in the study. Apparently healthy controls were selected from the group of people who were attending for annual health check-up and found to be healthy. Results: On comparison between the two groups, the present study observed significant differences in the values of MDA, TAC, and reduced glutathione. Interestingly, we observed higher levels of MDA in the subjects suffering with breast carcinoma, whereas lower levels in the apparently healthy controls incorporated in the study. Comparing between the groups of LDL and HDL level, the present study observed significant difference. Conclusion: The present study concludes that alterations in the study parameters in breast cancer group are due to dys-balance oxidants production and lower expression of antioxidants.

Background: In our country, there has been little study on breast cancer individuals during and progression of the cancer on magnesium, and copper have not been considered in existing studies. Aim: To determine the effect of serum magnesium, and copper in breast cancer subjects and to compare them with the apparently healthy controls. Methods: Lately diagnosed female subjects with breast cancer in the age group of 40-60 years were included in the study. Apparently healthy controls were selected from the group of people who were attending for annual health check-up and found to be healthy. Results: On comparison between the two groups, the present study observed that serum copper level was lower in case of apparently healthy controls than breast cancer subjects. Comparing between the groups of serum magnesium level, the present study observed significant difference. Similarly, the serum copper level was also found to be significantly differed when compared between the two groups. Conclusion: The altered values of magnesium and copper are responsible for the initiation of breast cancer. In addition, present study implies that serum copper can be used as biomarkers for early identification and diagnosis of breast cancer.