A simple, precise, accurate and economic simultaneous UV spectrophotometric method has been developed for the estimation of Paracetamol, Chlorpheniramine Maleate, Phenylephrine Hydrochloride and Caffeine in tablet formulation. The estimation was based upon the measurement of absorbance at absorbance maxima of 245 nm, 260 nm, 269 nm and 275 nm for Paracetamol, Chlorpheniramine Maleate, Phenylephrine Hydrochloride and Caffeine in water, respectively in tablet dosage form. The method was then validated for different parameters as per ICH (International Conference on Harmonization) guidelines.