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365enates from normal or tolerant mice after biturates cannot be the sole mechanism rereceiving an L.D.,b0 dose af thiopental. sponsible for barbiturate hypnosis. 4 m It is the observed in Received May 15, 1950. P.S.E.B.M., 1950, ~7 4 vitro d,epression of brain respiration by bar-

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virtue of this capture, thyroidal accumulation centration to values which are greater than of iodide and tissue content of iodide is re-normal. When the iodine affinity of the drug duced to a level much lower than normal. remaining in the body is satisfied, then thy-IYhen the drug is administered daily, "a roidal accumulation of iodine returns to steady state" of drug concentration is achieved normal levels. in the body. The presence of the drug in thetissues of the body increases their iodine con-

No abstract