Correspondent: Anu Aalto, anu.aalto@hotmail.com, tel.+358 40 55232953 Précis: Combination of treatments is the most effective option for vulvodynia patients in terms of pain reduction. 4 AbstractObjectives: 8 % of women suffer from vulvodynia (VD), a chronic pain disorder with unknown etiology. Aims of our study were to assess the efficacy of given VD treatments measured by numerical self-reported pain score (NRS) and patients' quality of life.Methods: Study material consisted of a retrospective VD patient cohort (n=70). Data was collected by postal questionnaires and review of the medical records.Results: We report here a statistically significant reduction in NRS only with combination of therapies (median NRS before treatments 8 vs. median NRS 4 after treatments, p<0.001) but not with any individual therapy alone i.e. physiotherapy, topical medications, oral pharmaceutical therapy, sexual counseling by a trained nurse, sacral neuromodulation, laser treatment or surgery. Older age (>30) and frequent (≥6) outpatient clinic visits associated with a significantly minor reduction in NRS (p=0.03 and p=0.04, respectively).Conclusions: The results of this retrospective study suggest, that an effective, multimodality-based treatment is most beneficial for VD patients, and VD at older age may represent a subtype more resistant to therapy.