This study demonstrated for the first time the mechanisms involved in the topical anti-inflammatory effect presented by the semisolid containing A. moluccana dried extract pointing as the main mechanism is the reduction in the leukocyte migration and consequently resulting in diminished levels of cytokins and chemokines, indicating this herbal product as a promissor anti-inflammatory phytomedicine to treat skin inflammatory diseases.

Context: The aerial parts of Sphagneticola trilobata (L.) Pruski (Asteraceae) are popularly used to treat topical inflammation, but have not been fully investigated. Objective: To identify polar compounds in S. trilobata extracts and develop a new topical phytomedicine based on the kaurenoic acid (KA) content while monitoring and demonstrating its topical anti-inflammatory activity. Materials and methods: Ethanol spray-dried extract of S. trilobata was analysed by LC-MS while the KA content from semisolid was analysed by LC-UV. The extent of ear edema induced by applying 20 lL of croton oil (2.5%), arachidonic acid (AA; 2 mg/ear) and decanoylphorbol-13-acetate (TPA; 2.5 mg/ear) in mice was used to evaluate the biological activity of the semisolids, which were applied 30 min before the phlogistic agents. Results: Eight phenylpropanoids and four oleanane-type triterpenoid saponins were identified, majority of them reported for the first time in this species, in addition to KA. The semisolid containing 1.0% of dried extract reduced the ear edema induced by croton oil [77.2 6 4.5%; ID50 ¼ 0.49 (0.28-0.87%)], TPA (81.5 6 2.4%) and AA (39.1 6 6.9%), with decreasing effect at higher KA concentrations. This was accompanied by neutrophil migration inhibition as investigated by biochemical and histological assays. Discussion and conclusion: The anti-inflammatory effects were (at least in part) due to the interference in protein kinase C (PKC) activation, AA-cascade products and neutrophil migration inhibition, demonstrating the efficacy of the folk topical usage of this plant. The results support the development of a novel topical anti-inflammatory phytomedicine properly standardized to treat inflammatory dermatological diseases. ARTICLE HISTORY

O presente artigo tem como objetivo descrever a abordagem conceitual e o processo de implementação da Universidade da Criativa Idade, projeto de extensão universitária da Universidade Vale do Itajaí [Univali]. A Universidade da Criativa Idade é fundamentada no comportamento de pleasure growers e objetiva proporcionar lazer e novos conhecimentos para pessoas acima de 50 anos. Trata-se de um estudo descritivo, do tipo relato de experiência. O projeto teve início com a oferta de um curso de extensão sobre os eixos de formação e as temáticas relacionadas às matrizes curriculares dos cursos de graduação das áreas de Comunicação, Turismo e Lazer da Univali, para 30 participantes e 10 professores. A partir da análise do primeiro ano de funcionamento do projeto constatou-se que o conceito de lazer como prática social vinculado à educação esteve presente nas atividades realizadas, evidenciando também, aspectos relacionados ao turismo pedagógico associando lazer e educação.