It has been observed that in many cases one infection can partially protect against another infection or it may lead to a co-infection. For instance, the interaction between infections with different strains, like dengue and malaria or tuberculosis and lepra, induces cross immunity. On the other hand, individuals infected with HIV are much more susceptible to other infections, for instance, tuberculosis. We propose a compartmental model to describe the transmission of AIDS and tuberculosis in a closed community as an example of one infection activating the other one. When studying the dynamics of the interactions we obtain basins of attraction where one infection prevails over the other one and where both infections coalesce. Furthermore, we are taking into account an adaptation of the model in order to assess the transmission coefficients for HIV and Mycobacterium tuberculosis infections among women inmates.
In order to achieve a better understanding of multiple infections and long latency in the dynamics of Mycobacterium tuberculosis infection, we analyze a simple model. Since backward bifurcation is well documented in the literature with respect to the model we are considering, our aim is to illustrate this behavior in terms of the range of variations of the model's parameters. We show that backward bifurcation disappears (and forward bifurcation occurs) if: (a) the latent period is shortened below a critical value; and (b) the rates of super-infection and re-infection are decreased. This result shows that among immunosuppressed individuals, super-infection and/or changes in the latent period could act to facilitate the onset of tuberculosis. When we decrease the incubation period below the critical value, we obtain the curve of the incidence of tuberculosis following forward bifurcation; however, this curve envelops that obtained from the backward bifurcation diagram.
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