Palladium catalyzed Suzuki-Miyaura (SM) and Buchwald – Hartwig (BH) cross-coupling reactions of some phenoxazines are reported.  The precursor  9,11-diamino-6-chloro-7-oxa-8,10,12-triaza-benzo [a] anthracen-5-one  was prepared by anhydrous base mediated reaction of  2,5,6-triamino-pyrimidin-4-ol  and 2,3-dichloro-1,4-naphthoquinone in methanol. The molecular structures of the synthesized compounds agreed with UV/visible, FT-IR, 1H-NMR, MS and elemental analysis data. Using Ciprofloxacin and Ketoconazole as reference drugs, the compounds were screened against six (6) micro-organisms, viz: Listeria ivanovii, Staphylococcus aureus, Klebsiellapneumoniae, Escherichia coli, Candida albicans and Aspergillusnigerand were found to show significant activity against L.ivanovii and E. coli bacteria.