Since the revealing of the SARS-CoV-2 virus, the broad clinical spectrum of COVID-19 and, especially, the acute severe respiratory syndrome, have alarmed the whole medical world. The pathogenesis of COVID-19 is complex and unknown since the beginning of the pandemic. Many proinflammatory cytokines, including interleukine-6 (IL-6), are involved in the occurrence of cytokine release syndrome, having an important role in the severe evolution and death of COVID-19 patients. For evaluating the role of tocilizumab (TCZ), an anti-IL-6 agent, we analysed the survival in 149 COVID-19 patients from the first day of therapy until the next 90 days of follow-up. Less than half of patients (18.79%) died. The mean survival period was 75.05 days. The evolution of the inflammatory syndrome was favourable at 3 and 7 days, after TCZ administration, with a statistically significant decreased amount of fibrinogen, erythrocyte sedimentation rate, and C-reactive protein. The risk factors of death rate were age over 60 and pre-existing co-morbidities, as heart disease and obesity. The administration of TCZ in severe COVID-19 patients as in other studies was beneficial. RezumatDupă apariția virusului SARS-CoV-2, spectrul clinic larg al COVID-19 și, în special, sindromul respirator acut sever au ridicat un mare semn de îngrijorare în întreaga lume medicală. Patogenia COVID-19 a fost complexă și necunoscută la începutul pandemiei. Multe citokine proinflamatorii, inclusiv interleukinele IL-6, sunt implicate în sindromul de eliberare a citokinelor, cu rol important în evoluția severă și decesul bolnavilor COVID. Pentru evaluarea rolului tocilizumab-ului (TCZ) ca medicație anti-IL-6, am analizat supraviețuirea în rândul a 149 pacienți COVID-19 monitorizați 90 de zile de la inițierea tratamentului. Mai puțin de jumătate dintre pacienți (18,79%) au decedat. Durata medie de supraviețuire a fost de 75,05 zile. Evoluția sindromului inflamator a fost favorabilă, cu reducerea semnificativ statistică a valorilor fibrinogenului, vitezei de sedimentare a hematiilor și proteinei C reactive. Factorii de risc ai ratei de mortalitate au fost vârsta peste 60 de ani, afecțiunile cardiace preexistente și obezitatea. Administrarea de TCZ la pacienții cu forme severe COVID-19, ca și în alte studii publicate, s-a dovedit a fi benefică.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.