The aim of this study was to evaluate specific chromatic alterations induced by white mineral trioxide aggregate after final irrigation with sodium hypochlorite. Sixty specimens were prepared mechanically and filled with mineral trioxide aggregate after different final irrigation protocols: Group 1 -distilled water, Group 2 -sodium hypochlorite followed by distilled water, Group 3 -sodium hypochlorite, only. Colour changes were recorded with a spectrophotometer at baseline, and then after 1, 2 and 4 months. The Commision Internationale de l' eclairage colour system was used and the total colour changes DE were calculated. In groups where sodium hypochlorite was used, parameter L* decreased significantly after the first month (Group 2 (P < 0.006), Group 3 (P < 0.009)). Group 3 demonstrated greater colour change DE than Group 1, after the first month (P < 0.02). In conclusion, white mineral trioxide aggregate can lead to tooth discolouration by contact with sodium hypochlorite residues in dentinal tubules.