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An environmentally benign and metal-free synthesis of 4-aryl quinolines is reported by employing readily available arylamine, arylacetylene, and DMSO in the presence of 20 mol% p-TSA•H2O. In the present protocol,...

An environmentally benign synthesis of 2,3-diarylylquinoline is reported via a one-pot three-component reaction from aryl amines, benzaldehyde, and styrene oxide in the presence of 20 mol% p-TSA●H2O at 120oC. This protocol does not require metal catalysts, additives, and extra oxidants. Mechanistic studies confirm the crucial role of p-TSA●H2O and the use of air as the sole oxidant makes this transformation very attractive. The salient feature of this protocol is easy handling, broad substrates scope, shorter reaction time, high atom economy and regioselectivity, good yields and the formation of one CN and two CC bonds take place in a single step.