Acute pulmonary embolism is a component of venous thromboembolism (VTE), which may prove fatal if not suspected and subsequently treated. Here we present a 82 year female patient with Bronchial asthma who de-teriorated and developed pulmonary thromboembolism during the hospital stay. Acute pulmonary embolism in elderly asthmatics is not very uncommon. Asthmatic presenting with acute onset of dyspnea, pulmonary embolism should be kept as a possibility. most of the time PE is not considered in differ-ential diagnosis while evaluating such patients in emergency. Pulmonary embolism requires high clinical suspi-cion, based on validated scores and requires further multi-modality investigation to confirm or rule out disease. Key words: Acute Pulmonary Embolism, Bronchial Asthma, High Clinical Suspicion