Background Although the effect of isotretinoin use on hormonal changes in acne pathogenesis is not fully known, there are limited studies on its effects on the development of hirsutism. In this study, it was aimed to evaluate the effect of isotretinoin use on hirsutism and hormonal parameters in patients with acne vulgaris. Methods In this study, 30 female acne patients and 30 healthy females were evaluated prospectively. Menstrual irregularity, LH, FSH, prolactin, progesterone, 17‐OH progesterone, oestradiol, total testosterone, DHEA‐S, insulin, glucose, TSH levels, Ferriman‐Gallwey (FG) score and ultrasonography (USG) findings of control group and patient group were recorded. Results Pre‐treatment progesterone (P = .007) and oestradiol (P = .001) levels of the patients were statistically lower than the control group. In the patient group, menstrual irregularity (P < 001) and FG hirsutism score at the third month of treatment were significantly higher than before treatment. In 10% of the patients, there were abnormal findings on pelvic USG in the third month of treatment. Conclusion In our study, it could not be revealed that isotretinoin has a significant effect on pituitary, adrenal hormones and insulin resistance. We found that 3 months of isotretinoin treatment caused an increase in menstrual irregularity and FG hirsutism score.

IntroductionSome previous studies reported autoimmunity as an etiologic factor in chronic urticaria (CU), but the results of some autoimmunity tests in these studies are conflicting.AimTo concretize whether there was any relation of autologous serum skin test (ASST) and autologous plasma skin test (APST) results with sex, age and urticarial activity score (UAS) in patients with CU.Material and methodsFifty patients with CU and twenty healthy subjects admitted to our dermatology clinic were included in the present study. The ASST and APST were applied to all individuals.ResultsThe positiveness rates of ASST and APST were significantly higher in the patient group than controls (p = 0.027, p = 0.001, respectively). Among patients, the APST positiveness rate (72%) was significantly (p < 0.05) higher than ASST (46%). It was seen that 48% of patients with negative ASST results had positive APST. However, no patient with negative APST results had positive ASST. There were significant (p < 0.05) relations of the tests’ positiveness rates with sex and old age but with UAS. The diameter of the erythematous papule was remarkably (p < 0.05) larger in APST than ASST and also significantly (p < 0.05) larger in females compared to males in both tests (p < 0.05). It was positively increased with old age (p < 0.05).ConclusionsWe can suggest that APST is more sensitive than ASST in the assessment of autoimmunity in CU. A high positiveness rate of APST results may be attributed to high numbers of autoantibodies and coagulation factors present in plasma that might probably play a role in etiopathogenesis of CU.

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Idiopathic atrophoderma of Pasini and Pierini (IAPP) is a type of rarely seen dermal atrophy which little sunken from the skin, characterized with sharp edged plaque lesion. Lesions frequently placed symmetrically and not cause to subjective complaint. It is not certain whether IAPP is a different entity or it is a primary atrophic variant of morphea. Seventeen year-old male patient applied to our clinic with complainant of many slightly sunken from skin brown color spots that settle the front of body and at the middle line of back. The patient was diagnosed of IAPP according to clinical and histopathological findings. In this case of presentation, the clinical and histopathological features of the IAPP has been described and other atrophic dermatosis and their distinctive features have been excluded in the discussion.

ÖzetAmaç: Yatırarak takip ettiğimiz akut ürtikerli ve anjioödemli hastaların klinik ve etyolojik özelliklerinin belirlenmesi ve laboratuvar tetkiklerinin gerekliliğinin değerlendirilmesi. Gereç ve Yöntem: Bu çalışmaya yatırarak tedavi ettiğimiz 105 akut ürtiker ve anjioödemli hasta alındı. Lezyonların özellikleri ve hastaların klinik özellikleri sorgulandı. Ayrıca lezyon sayısı, şiddeti ve ürtika plak çapı kaydedildi. Hastalardan rutin hematolojik ve biyokimyasal tetkikler, tiroid fonksiyon testleri, hepatit belirteçleri, gaytada parazit, total IgE, kültürler, eritrosit sedimantasyon hızı, C-Reaktif protein, antinükleer antikor, PA akciğer grafisi ve gerekli hastalarda psikiyatri konsultasyonu istendi. Bulgular SPSS 15,0 istatistik programına kaydedildi ve yüzde (%) verilerek yazıldı. Bulgular: Hastalarımızın 28'i sadece ürtiker (%26,7), 7'si sadece anjioödem (%6,7), 70'i ürtiker ve anjioödemdi (%66,7). Eşlik eden en sık semptom kaşıntı (%91,4) ve yanma hissi (%34,3) idi. En sık sistemik semptom olarak %15. Sum maryBackground and Design: To determine the clinical and etiological features of inpatients with acute urticaria and angioedema and to assess the need for laboratory tests. Material and Methods:We recruited 105 patients with acute urticaria and angioedema who were admitted to our inpatient unit. The lesions and the characteristics of the patients were analyzed. Routine diagnostic tests including complete blood count, thyroid function tests, hepatitis panel, stool parasite, total IgE levels, cultures, erythrocyte sedimentation rate, C-reactive protein, anti-nuclear antibody, and posterior anterior lung X-ray were ordered. A psychiatric consultation was obtained, when needed. The results were analyzed with SPSS 15.0 statistical software. Results: Among 105 patients, 28 (26.7%) had urticaria, 7 (6.7%) had angioedema, and 70 (66.7%) suffered from both urticaria and angioedema. The most common accompanying symptoms were itching (91.4%) and burning (34.3%). The most common systemic symptoms were fatigue (15.2%) and headache (12.4%). The lesions usually appeared in the evening hours (24.8%). Twenty-five patients were waking up due to itching during the night. Some lesions were associated with physical activities.