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Background: Intensive care units (ICUs), despite advances in critical care nursing, have frequent issues with early diagnosis and adequate treatment. Recently discovered world-class procalcitonin (PCT), a revolutionary laboratory marker, has been shown to be useful in this regard. The objective is to Comparison of concentrations of serum procalcitonin (PCT) and c-reactive protein (CRP) with a comparable level of organ malfunction during sepsis and evaluation of the interaction between serum PCT and CRP concentrations with different organ malfunction occurrence in sepsis. Design: It is a Hospital-Based Prospective study. Participants and Setting: Fifty people were admitted to the intensive care unit of Gandhi Medical College. Subjects and Methods: The extent of sepsis-related organ impairment was evaluated with the sequential organ failure assessment (SOFA) on day 1. Patients were identified by category 1(0-6), category 2(7-12), group 3(13-18), and group 4(19-24) in 4 separate classes with varying organ impairment seriousness of sepsis. Serum PCT and CRP concentrations have been measured. Results: The majority of the patients belonged to the age groups of 60-69 years (30%) and 50-59 years (22%) Majority of the patients belonged to the Sofa group 1 around 42% followed by sofa group 2 with 38%, sofa group 3 with 16% and the least belonged to the sofa group 4 with 4%. The mean PCT and CRP concentration in those who survived was 14.73 ng/ml and 149.916mg/L respectively and in those who died were 45.76 ng/ml (p-value <0.001) and 183.584 mg/L (p-value 0.172) respectively. The linear correlation between PCT plasma concentrations and the four groups was significantly stronger than with CRP. Conclusion: In SOFA and serum PCT, The level of organ dysfunction and complications in sepsis patients is closely related to serum CRP levels.

Background: Obesity exists worldwide at a large incidence rate. All systolic and diastolic blood pressure show a strong association with the height and weight of both sexes. This research was intended to establish the incidence of hypertension in obese patients relative to findings reported in non-obese persons. The objective is to research Hypertension in accordance with the Body Mass Index and to equate it between the two classes of Obese and Non-Obese persons. Subjects and Methods: The following anthropometric tests were carried out of both such patients Height 2. Weight 3. Circumference of dimension 4. The hip circumference. The Body Mass Index and the Waist Hip Ratio is determined from these measures. Blood pressure monitoring of BP was taken three times to validate systemic hypertension. Careful history was first taken of these cases involving pre-existing chronic hypertension and disease diagnosis. Results: The pre-hypertension level saw more people from both Obese and non-obese classes. Prevalence of stages 1 and 2 of hypertension was mostly seen in obese people. The mean systolic and diastolic blood pressure was higher in obese males than females but barely any noticeable variation in the waist circumference of > 100 and in the waist circumference of 90-100 cm, males were greater than females. Conclusion: The incidence of elevated blood pressure and mean systolic and diastolic blood pressure in increased BMI classes, i.e. obese people, was far higher. High BMI demonstrated a strong hypertension association.

PCOS is a hormonal disorder common among women of reproductive age. Patients with PCOS are known to have a high incidence of insulin resistance. Serum magnesium (Mg) is often associated with insulin resistance among patients with PCOS. This case - control study was conducted at SRM Medical College Hospital and Research Centre, Tamil Nadu, India. Total of 62 participants between the age group of 20- 40 years were recruited in the study, in which 31 were healthy controls and 31 were cases with PCOS. FBG, HbA1c, lipid profile, serum magnesium, serum insulin was estimated. Students ‘t’ test was done to compare the mean levels between groups. Low serum magnesium, higher levels of insulin and insulin resistance is seen in PCOS compare to non-PCOS group. The correlation of analysed biochemical parameters were done among PCOS group. Negative correlation of mg with insulin, FBS and HOMA-IR was observed. The evidence showing that low serum magnesium is associated with insulin resistance in PCOS individuals.