Post stroke patients need medical rehabilitation to live an independent life. Nintendo Wii technology presents an alternative choice that is quite safe, feasible, and has a high potential in rehabilitating & restoring motor function in post stroke patients. Although it has been widely used as adjunct therapy in stroke rehabilitation facilities throughout the world, only a few acknowledge its effectivity in post-stroke patients. This study aims to conduct a systematic review in order to identify and assess the results used in evaluating Nintendo Wii technology as rehabilitation therapy for stroke patients. Thus, the study used for this research is systematic review. Materials included in this study are research/studies found in NCBI, PubMed, Cochrane and other relevant online databases. From this research, it is found that Virtual Reality (VR) such as Nintendo Wii considered as an additional rehabilitation therapy that provides a significant improvement in various aspects of exercise therapy, such as; balance; walking ability; statistical and dynamic strengths; motivation as well as socialization; and recovery of physical function in stroke patients. Nintendo Wii can also be used safely in stroke patients and there have been no reports of side effects from this therapy.

Background: Asia has the highest cardiovascular disease mortality worldwide, with most of these deaths occurring in low-income developing countries (lower- and middle-income countries [LMIC]). When compounded with issues in LMICs, such as minimal health resources and inadequate access to health facilities, these challenges make early detection efforts utilizing sophisticated diagnostic tools challenging. Earlobe crusade (ELC), an atherosclerosis marker, is the solution. Objective: This research assessed the relationship between ELC and coronary artery disease (CAD) evidenced by coronary angiography (CAD-CAG-confirmed) in LMIC Asian populations. Methods: This study followed the Preferred Reporting Items for Systematic Review and Meta-Analysis approach to identify studies on the connection between ELC and CAD-CAG-confirmed in LMIC Asian populations. LMIC classification in Asia based on World Bank statistical data through 2021. This study searched MEDLINE, Embase, ProQuest, and Scopus using population, intervention, comparison, and outcome criteria. Then, the risk of bias and diagnostic value was evaluated. Results: This systematic review found six articles with 1657 participants. All studies showed a significant relationship between the presence of ELC and CAD. ELC diagnostic values for CAD, sensitivity 74%–98%, and specificity 52.5%–91.49%. Several multivariate regression analysis studies showed that ELC was independently associated with CAD. Conclusion: The ELC examination is the best option for CAD screening in countries with limited resources and health facilities. ELC is straightforward, affordable, and valuable as a CAD diagnostic marker.

METHODS Study designThis study aimed to determine the association between diabetes and hypertension as the risk factors for AKI in COVID-19 patients. Therefore, we calculated the combined odds ratio (OR) and a 95% confidence interval (95% CI) using a random or fixed-effect model. To ensure the quality of our study, we created a meta-analysis using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist 8 .

Genetic variation at chromosome 8q24 is considered as the potential biomarker for prostate cancer. We aimed to assess the relation between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer. Material and Methods: A meta-analysis was carried out in January to June 2020 by collecting relevant studies through online databases. The correlation and estimated effect between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer were analyzed using a Z test. Results: A total of 16 relevant studies were selected (16,842 cases and 18,258 controls). In overall, T allele and CT genotype of 8q24 rs10090154C>T gene polymorphism increased the risk of prostate cancer (OR95%CI=1.238 [1.14-1.34], p<0.001; OR95%CI=1.238 [1.14-1.35], p<0.001) while CC genotype and C allele had protective effect (OR95%CI=0.800 [0.74-0.87], p<0.001; OR95%CI=0.808 [0.75-0.88], p<0.001). Subgroup analysis of Caucasian population revealed that T allele of 8q24 rs10090154C>T was associated with increased risk of prostate cancer (OR95%CI=1.285 [1.07-1.54], p<0.001), while C allele had protective effect (OR95%CI=0.778 [0.65-0.93], p=0.007). In Asian population, CT genotype of 8q24 rs10090154C>T was correlated with increased risk of prostate cancer (OR95%CI=1.302 [1.17-1.45], p<0.001), while CC genotype had protective effect (OR95%CI=0.770 [0.64-0.92], p=0.005). Conclusion: Our meta-analysis confirmed that 8q24 RS10090154C>T gene polymorphism had strong association with the risk of prostate cancer.

Background: Prostate and colorectal cancer are the second and third most common cancer in male. Radiotherapy is performed as treatment option for both cancers. Thus, lead to the increasing case of radiotherapy-induced urethral stricture. Recurrent stricture post-correction commonly occurs.Methods: Six relevant English literatures were found throughout online database published between 2011-2017. PICO is used to identify components of clinical evidence to create systematic review. Subjects include 222 radiotherapy-induced urethral stricture patients due to prostate and colorectal cancer who undergone various treatment modality options.Results: Radiotherapy modality performed in sample population were External Beam Radiotherapy (EBRT) (44.1%), Brachytherapy (BT) (31.5%), EBRT/BT (16.2%), Adjuvant EBRT (6.8%), salvage EBRT (0.9%), and proton beam (0.5%). Strictures were found in bulbomembranous-urethra (64.4%), bulbar-urethra (17.1%), posterior-urethra (10.8%), membranous-urethra (5.4%), vesico-urethra (1.4%), and pan-urethra (0.9%). Known mean onset for urethral-induced radiotherapy is 5.6 years. Treatment options include anastomosis urethroplasty (61.3%), Buccal Mucosa Graft Urethroplasty (23.4%), urolume stent (10.8%), penile island flap onlay (2.2%), Genital fasciocutaneous skin flap (1.4%), and perineal flap urethroplasty (0.9%). Known mean onset for urethral stricture recurrence is 10.8 months.Conclusion: Urethral strictures commonly occur after radiation therapy for prostate and colorectal cancer. Urethroplasty is the preferable treatment option. The recurrence onset for urethral stricture post urethroplasty is shorter than urethral strictures in general.