Background & Aim: Academic self-efficacy implies a person's belief in his or her abilities in achieving educational goals and activities, the formation of which is influenced by various factors. This study was conducted to determine the relationship between family cohesion and academic self-efficacy in students of Kurdistan University of Medical Sciences in 2015-2016. Methods & Materials:In this cross-sectional study the statistical population was Kurdistan University of medical sciences students, among whom 500 were studied. In this study, random stratified sampling with proportional allocation was used and each faculty was considered as a category, and the final samples were randomly selected from the classrooms from each faculty considering the share of the students of that faculty. Data were collected by Fischer Family Integrity Questionnaire and Educational Self-Efficacy Questionnaire. After completing questionnaires by the students, the data were analyzed using SPSS version 20. Results: The mean score of family cohesion among the students was 59.07±11.24 and the mean score of the academic self-efficacy of the students was 103.45±18.88. There was a positive and significant relationship between academic self-efficacy and family cohesion among students (r=0.43, p<0.001). Conclusion:It is recommended to hold educational classes on the importance of families and their togetherness, as well as good and appropriate emotional relationships with each other for parents in health centers in Sanandaj.