Cosmetics are a necessity in everyday life. Facial serum is a skin care product that contains a light gel or lotion with a moisturizer that has active ingredients that can penetrate deeper into the skin. UV rays can cause damage to collagen / elastin in the skin, hyperpigmentation, inflammation and dehydration. In addition, it can also damage skin components such as increasing fine lines, wrinkles and brown spots that trigger premature aging. Therefore, antioxidants are needed to ward off free radicals. The purpose of this literature review is to provide information to readers about what plants have the potential as antioxidants in the preparation of facial serum formulas. The method used in this literature review is using database searches in the form of Google Scholar, PubMed and ResearchGate (2010-2021). Based on the results of the literature review, 11 journals were obtained, with various plants including green coffee extract (Coffea canephora Var. robusta), temu giring rhizome extract (Curcuma heyneana), tamarind seeds (Tamarindus indica L.), cocoa pods ( Theobroma cacao L.), red dragon fruit skin (Hylocereus polyrhizus), red algae (E. cottonii), lychee fruit skin (Litchi chinensis Sonn.), wangon leaf (Olax psittacorum (Willd.) Vahl.), green coffee beans ( Coffea robusta L), turmeric rhizome (Curcuma domestica), and plantain (Musa X paradisiaca L.). Of all these types of plants that have antioxidant activity in serum preparations that are classified as very strong, namely green coffee beans (Coffea robusta L.) while the antioxidant activity of the extract category was very strong, namely Lychee (Litchi chinensis Sonn.).