NORMAH AWANG, SITI MUSSLIHAH SHAHIDI, ASMAH HAMID & NURUL FARAHANA KAMALUDIN ABSTRAK Kesan sitotoksik sebatian organostanum (IV) terhadap pelbagai sel kanser telah dikaji oleh para saintis di seluruh dunia.Dalam kajian ini,dua sebatian baru organostanum (IV) iaitu difenilstanum (IV) etilfenilditiokarbamat (DFEF) dan difenilstanum (IV) butilfenilditiokarbamat (DFBF Cytotoxicity of organotin (IV) compounds towards various types of cancerous cells have been extensively studied by researchers worldwide. In this study,two new organotin (IV) compounds; diphenyltin (IV) ethylphenyldithiocarbamate (DFEF) and diphenyltin (IV) butylphenyldithiocarbamate (DFBF) were used to evaluate their cytotoxic effect against erythroleukemia cells, K562. K562 cell was used as target cell whereas Chang liver and V79 fibroblast cells were used to evaluate the effects of both compounds on non-cancerous cells. The cytotoxic effects of both compounds were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)