Pendahuluan: Sistem Manajemen Keselamatan serta Kesehatan Kerja merupakan bagian dari sistem manajemen risiko umum perusahaan yang mencangkup kebijakan dan komitmen, perencanaan, pelaksanaan, pengukuran serta evaluasi. Tujuan: Untuk mengetahui pelaksanaan sistem manajemen keselataman dan Kesehatan kerja yang di terapkan di PT. Bosowa beton Indonesia apakah sesuai dengan Peraturan Pemerintah Republik Indonesia Nomor 50 Tahun 2012. Metode: Jenis penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologis dengan informan berjumlah 9 orang. Hasil: Menunjukkan bahwa penerapan SMK3 suda dilaksanakan berdasarkan PP No 50 Tahun 2012 yang mencangkup yang mencangkup kebijakan dan komitmen, perencanaan, pelaksanaan, pengukuran dan evaluasi. Serta pemantauan dan evaluasi. Kesimpulan: dalam pelaksanaan SMK3 masi terdapat kendala mulai pengadaan APD yang sering kali terlambat, rendahnya budaya disiplin k3 serta lemahnya sangsi yang di berikan terhadap pekerja yang melanggar ketentuan. Serta kurangnya SDM yang berkompeten membuat pengawasan area kerja yang begitu luas tidak bisa di lakukan secara bersamaan

Thrombocytopenia is a disease characterized by a decreased platelet count. Some of the causes are decreased platelet production, increased platelet use, such as due to infection, and autoimmune causes, namely the loss of tolerance of the immune system to self-antigens on the surface of the platelets and megakaryocytes marked with a platelet count <100,000 / μL and based on the pathomechanism classified as primary Immune Thrombocytopenia (ITP) and secondary, as well as several other causes. IL-4, one of the cytokines produced by Th2 which stimulates B cells to increase antibody production. The aim of this study was to compare IL-4 levels in primary ITP patients and non-primary ITP tombocytopenia. This study involved 30 primary ITP subjects and 30 non-ITP primary tombocytopenia subjects obtained based on data medical records, examination of IL-4 cytokine levels by the ELISA method. The results of this study that the IL-4 levels of the primary non ITP tombocytopenia subject group were higher than the primary ITP subject group, which means that there were differences in IL-4 levels in the primary ITP subject group and the non-ITP primary tombocytopenia subject group.

Conceptually, Cognitive Behavior Therapy is a pattern of human thought formed from a series of interrelated Stimulus-Cognition-Response processes, in which cognitive processes cause a person to feel and act. Since the CBT technique was carried out at LRKM Mitra Husada, specific measurements have never been carried out to see its effect on changes in the self-esteem of the clients who were given the intervention. This study aims to analyze the effect of cognitive behavioural therapy on the self-esteem of methamphetamine users at LRKM Mitra Husada, Foundation of Mitra Husada, South Sulawesi. This study used the Quasi Experiment method with the research design used being the Pretest-Posttest with Control Group Design, using two groups, namely the intervention group that was given the Cognitive Behavioral Therapy Counseling treatment and the control group that was only given a brochure. The results of this study found that there was an effect of Cognitive Behavioral Therapy (CBT) counselling interventions on the self-esteem of methamphetamine users, where the average pretest result was 1.61 and 2.67 post-test with a significance value of 0.000 (p <0.05 ); There was no effect of giving brochures on the self-esteem of methamphetamine users, where the average pretest result was 1.78 and 1.94 posttest with a significance value of 0.257 (p> 0.05); While the results of the comparative test between the intervention group and the control group found that there was no significant difference in the effect on the control group before and after being given the brochure (p-value 0.257) but found differences in the effect on the intervention group before and after being given CBT counselling (p-value 0.000).