Innovative high porosity SCR substrates are targeting at optimum utilization of high catalyst amounts without increasing pressure drop. Mathematical modeling of such technologies is challenging, requiring accurate description of both chemistry and mass transfer inside the active material. In this work, a systematic experimental study is conducted towards calibrating a comprehensive commercial simulation model for a Cu-zeolite SCR catalyst. Based on the calibrated model, it is possible to evaluate different substrate technologies with respect to NOX conversion, pressure drop and packaging volume reduction potential.