Twenty-three premature ejaculators (PEs) and 11 control subjects were administered 25 mg of clomipramine in a double-blind, placebo-controlled, crossover design study. During 2-week trials, subjects took either the drug or the placebo 4 to 6 hours prior to sexual activity. Daily diary data revealed that, for both groups, orgasmic latency was significantly increased when taking the clomipramine. For the PEs, the average increase in orgasmic latency during intercourse was from less than 1 minute to more than 3.5 minutes. Subjects also participated in two laboratory sessions while on the drug and placebo. During these lab sessions they were exposed to erotic videos with and without the addition of vibrotactile stimulation to the penis. Results from the laboratory data support those from the diaries. Specifically, PEs were significantly less likely to reach orgasm during the lab sessions while on the clomipramine than while on the placebo. Further, they reported a significantly greater sense of control over their orgasm while on the drug. The results of this study, along with previous research, strongly support the value of low doses of clomipramine in the treatment of premature ejaculation, specifically when taken on an as-needed basis as little as 4 hours prior to sexual activity. It is important to note, however, that the beneficial effects of the drug were not uniform across clinical subjects. In this study, those PEs with the shortest orgasmic latencies while on the placebo were the least likely to substantially improve while on the drug. Additional research is necessary to determine whether changes in the timing and dosage of the clomipramine administration can extend the benefits of the drug to those with the shortest latencies.

I . Male guinea-pigs were assigned to four different groups at birth. The heaviest group of animals was severely undernourished from 21 d of age (weight gain: 1.2 g/d v. 10 g/d for normally-fed animals).2. At 35, 45, 55 and 65 d of age in normally-fed animals, and at 45 and 55 d of age in undernourished animals, blood testosterone levels were determined by radioimmunoassay, epididymidal tissue examined for the presence of spermatozoa and testes sectioned for rating of spermatogenesis using light microscopy. 3. Sexual maturity in terms of potential fertility (spermatozoa in the epididymis) was reached by all normally-fed animals between 45 and 55 d of age. High birth-weight animals had a higher incidence of the most advanced stages of spermatogenesis than low birth-weight ones at the various ages studied. In the undernourished animals spermatogenesis was clearly delayed.4. Plasma testosterone concentrations were already in the adult range at 35 d and independent of age and birth-weight. The undernourished animals, however, had very low levels. Maintenance of spermatogenesis seemed compatible with low plasma levels of testosterone.5. It is concluded that the timing of testicular development seems to be determined by the time the animals are born and appears to be unaffected by severe undernutrition from 21 d of age.Investigations using various species have indicated that puberty may start earlier in individuals that are large than in those that are small during growth. Investigations have been made in the rat by Kennedy & Mitra (1963) and in man by Tanner (1962). In the female guinea-pig clear correlations have been established between body-weight at birth and the rate of post-natal growth in body-weight (Lister & McCance, 1965) and with the age at which the vagina first opened (Slob et al. 1973).The present study was undertaken to examine the effects of body-weight at birth, and of undernutrition during growth, upon the time of onset of puberty in male guinea-pigs. Criteria for the onset of puberty needed to be established. Therefore, a mixed longitudinalcross-sectional growth study was carried out, in the course of which animals were killed at regular intervals. Testes and epididymidal tissue were examined for sperm production. Blood was collected for testosterone determinations. Part of this study has been reported previously (Slob et al. 1975). EXPERIMENTAL METHODSAlbino guinea-pigs (30-45 d pregnant) were purchased from a commercial breeder (randombred closed breeding colony; TNO, Zeist, The Netherlands). The breeding schedule was such that several litters were born on the same day. Thirty-eight females gave birth to a total of I 28 live young (seventy-seven males and fifty-one females); thirteen (five males and eight females) were stillborn or died shortly after birth. Within 1 2 h of birth (day of birth designated day 0) the pups were sexed and weighed to the nearest g. Within 2 d of birth several litters were mixed and redistributed such that each new 'litter' contained three or four male and female pups; ...

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Bisoprolol is an effective antihypertensive agent with no sexual side effects.

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