Artworks on paper include manuscripts, prints, drawings, collages, and paintings on paper. Their preservation requires strict values of microclimate parameters, in particular temperature, humidity, radiation and illumination. Maintenance of these parameters in exhibition spaces and storages is of vital importance for collection integrity. Paper as an art medium is particularly sensitive to these factors. Employment of HVAC (Heating, Ventilating and Air Conditioning) system is recommended in order to avoid unwanted fluctuations in microclimate conditions. Intelligent control system should be used for data acquisition and activation of HVAC system when needed. In that way, the live span of these sensitive artworks can be extended and preserved for future generations.