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The microstructure and mechanical properties of a low carbon steel containing 30 ppm boron have been investigated. The steel was subjected to various cooling conditions in a thermo-mechanical simulator to generate continuous cooling transformation (CCT) diagram. Similar cooling conditions were also applied to tensile samples in order to evaluate their mechanical properties. The results indicate profuse banding in the hot strip of thickness 2.5 mm. This effect is attributed to the presence of manganese. In addition, variation in cooling rate led to increase in strength but severely affected percentage elongation albeit in an acceptable limit of 6%. This effect is discussed in the light of degree of banding of strips and microstructural constituents generated during heat treatment of steel strips of different thicknesses.

Purpose: The objective of this study was to synthesize and statistically optimize dimethyl fumarate (DMF) loaded solid lipid nanoparticles (SLNs) for better management of multiple sclerosis (MS).Methods: SLNs were formulated by hot emulsion, ultrasonication method and optimized with response surface methodology (RSM). A three factor and three level box-behnken design was used to demonstrate the role of polynomial quadratic equation and contour plots in predicting the effect of independent variables on dependent responses that were particle size and % entrapment efficiency (%EE).Results: The results were analyzed by analysis of variance (ANOVA) to evaluate the significant differences between the independent variables. The optimized SLNs were characterized and found to have an average particle size of 300 nm, zeta potential value of -34.89 mv and polydispersity index value < 0.3. Entrapment efficiency was found to be 59% and drug loading was 15%. TEM microphotograph revealed spherical shape and no aggregation of nanoparticles. In-vitro drug release profile was an indicative of prolonged therapy. In-vivo pharmacokinetic data revealed that the relative bioavailability was enhanced in DMF loaded SLNs in Wistar rats.Conclusion: This study showed that the present formulation with improved characteristics can be a promising formulation with a longer half-life for the better management of MS.

Hydatid disease is a common condition in Libya. Between 1971 and 1976, hydatid disease accounted for 0.85% of total hospital admissions to Al-Jalah General Hospital, Benghazi. The incidence of hydatid disease reported in children below ten years of age was 11.7%. In this paper the experience of treating 56 children with hydatid disease is described. The presenting features, complications, surgical techniques and results are reported and discussed.