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Heterocyclic compounds containing pyrrole and indole-fused isocoumarins were obtained from a one-pot synthesis via annulations of N-heterocyclic carboxylic acids and alkynes with N ∧ O chelate ruthenium(II) complex, [RuCl(PySO 3)(p-cymene)] (PySO 3 = 2-pyridinesulfonate) in the presence of Cu(OAc) 2 H 2 O. The reaction proceeds efficiently in DMF but can also be performed in other solvents such as dichloroethane, t AmOH, and water. The annulations reaction is regioselective when performed 1-methylpyrrole-2-carboxylic acid with 1-phenyl-1-propyne.

The title reaction uses pyrrole‐2‐carboxylic acids and indole‐3‐carboxylic acids as starting material and copper acetate as oxidant.