This paper is a summary of a current European Union (EU)-funded project (1.5 M EUR, June 2009-April 2011) from the IPA (Instrument for Pre-Accession Assistance) 2007 programme, as part of the EU's assistance to healthcare in Serbia. The project's main objective is to improve the health-care system in the Republic of Serbia so as to create a safe, equitable, viable, and high-performance-oriented healthcare system where providers of care are stimulated to achieve continuously increasing standards of efficiency, effectiveness, and quality. Supporting the development of the Serbian Accreditation Agency for Healthcare Institutions and the challenges in assisting the Ministry of Health of the Republic of Serbia with continuous quality improvement at system level will be described, including the project achievements to date and analysis of results.